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Neurobiology and aetiology
Alzheimer’s disease research timeline
Alzheimer’s disease is not synonymous with dementia
Alzheimer’s disease is a neurodegenerative disease
What is neurodegeneration?
Risk factors
What factors are at play in Alzheimer’s disease?
Genetic risk factors
Modifiable and non-modifiable risk factors for dementia
Modifiable lifestyle factors and prevention strategies
Accumulation of dementia risk factors over time
Key points
Pathophysiological hypotheses
The aetiology of Alzheimer’s disease is complex
Amyloid hypothesis
Amyloid cascade hypothesis
Tau hypothesis
Tau protein pathology
Neuroinflammation
Metabolic dysregulation in Alzheimer’s disease
Key points
Development and importance of biomarkers to understand neurobiology
What are biomarkers?
Biomarker classification and biological staging of Alzheimer’s disease
Hypothetical biomarker model of Alzheimer’s disease pathophysiology
Why do we need biomarkers?
Potential use of accessible and cost-effective biomarkers in primary care
Summary
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10 warning signs of dementia
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