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image Image Chart showing progression of functional decline in Parkinson’s disease with different treatment approaches, from symptomatic benefit to disease modification.
Disease modification in Parkinson’s disease

Graphical representation of how various treatment strategies can impact disease progression in Parkinson’s disease, from symptom relief to potential cure

26.06.2025 Parkinson’s Disease
image Image Diagram showing how COMT inhibitors block the conversion of L-DOPA to 3-OMD, enhancing dopamine levels in the synapse in Parkinson’s disease.
Catechol-O-methyltransferase (COMT) inhibitors mechanism of action

Illustration of how COMT inhibitors increase dopamine availability in Parkinson’s disease by preventing the breakdown of L-DOPA

26.06.2025 Parkinson’s Disease
image Image llustration showing how MAO-B inhibitors prevent dopamine breakdown at the synapse, enhancing its availability in Parkinson’s disease
Monoamine oxidase type B (MAO-B) inhibitor mechanism of action at the synapse

Visual explanation of how MAO-B inhibitors help preserve dopamine levels in the synapse in Parkinson’s disease treatment

26.06.2025 Parkinson’s Disease
image Image Synaptic illustration showing how dopamine and dopamine agonists activate dopamine receptors in Parkinson’s disease treatment
Dopamine and dopamine agonists (DAs) at the synapse

Comparison of natural dopamine and dopamine agonists and their mechanisms of action at the synapse in Parkinson’s disease therapy.

26.06.2025 Parkinson’s Disease
image Image Infographic outlining both the advantages and challenges of levodopa as the standard treatment for Parkinson’s disease
Strengths and limitations of levodopa

Balanced summary of levodopa’s benefits and limitations in the long-term treatment of Parkinson’s disease

26.06.2025 Parkinson’s Disease
image Image Diagram showing how levodopa crosses the blood-brain barrier and is converted to dopamine in the brain, supported by peripheral DDC inhibition.
Mechanism of action of levodopa plus a peripheral dopa decarboxylase inhibitor

Illustration of how levodopa combined with a peripheral dopa decarboxylase inhibitor enhances central dopamine availability in Parkinson’s treatment

26.06.2025 Parkinson’s Disease

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