As outlined in the illustration, the various symptoms of depression can negatively impact a patient’s functioning, including in the areas of work or school, family life, and social life.1,2 Cognitive dysfunction and general dysfunction are linked, and both
have an impact on clinical outcomes in patients with depression.

file_download Download in HQ

Related content

image Image
Childhood trauma and antidepressant response
31.07.2025 Depression
image Image
Theoretical cycle of anhedonia

One hypothesis of the cycle of anhedonia (loss of interest or pleasure) in patients with depression is illustrated in this image; this hypothesis comes from a series of experiments performed on a sample of psychology students.

29.07.2025 Depression
image Image
The tolerability and safety profile of dopamine–serotonin receptor antagonists

As adjunctive treatment in MDD, some dopamine–serotonin receptor antagonists are associated with sedating side effects, while others are more often associated with ‘activating’ side effects.

29.07.2025 Depression